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Although technically challenging, this should be further investigated, especially in light of the neuroimaging findings in ME/CFS, described in the following paragraphs

& Ogilvie, J

Additionally, glutathione serves as a substrate for glutathione S-transferase (GST) enzymes that conjugate bile acids sequestering bile reduces the stimulatory effect bile has on colonic motility, compounding the constipation risk

Patients balancing work, family, and health appreciate this flexibility

This pathway maintains the physiological pulsatile pattern of GH release, in contrast to exogenous GH administration which provides continuous non-pulsatile delivery